Professor Ruby Huang is a renowned physician scientist in the international ovarian cancer (OC) and EMT (epithelial-mesenchymal transition) research fields with a research interest in cellular plasticity. In the field of EMT, she is best known to define the early events of EMT and to propose the paradigm shift of the EMT concept from binary to a continuous spectrum. Her group establishes the pan-cancer EMT signatures and defines EMT scoring. She utilizes OC as the working model to decipher the role of EMT spectrum in tumoral heterogeneity focusing on the transcription function of pioneer factors and the regulation at the 3D genome level. She is also the main contributor of the three seminal Cell review articles in EMT, which has accumulated citations up to 17,000+ times. In OC, she co-discovers the presence of five gene expression molecular subtypes (GEMS) that exhibit different epithelial/mesenchymal characteristics, therapeutic sensitivity, and identifies the dominant signaling pathways in each OC subtype. Her group further deciphers the intra-tumoral heterogeneity in OC by using deconvolution methods such as the Molecular Assessment of Subtype Heterogeneity (MASH) scheme and spatial omics profiling. Her recent work focuses on ovarian clear cell carcinoma (OCCC), an OC subtype with Asian significance, leading to the identification of epithelial/mesenchymal GEMS, the immune-related gene expression, and distinct spatial profiles in OCCC. As a pioneer of spatial omics research in the Asia Pacific region, Prof. Huang serves as the founding faculty of the Center of Excellence for Single cell and Spatial Genomics in NTUCC in collaboration with with 10x Genomics and YongLin Foundation. She is currently a Yushan Young Fellow supported by the Ministry of Education in Taiwan leading the EMPreSS (Epithelial Mesenchymal Precision Scoring Scheme) Lab. Prof. Huang is the 2025-2026 Vice President of TEMTIA, The EMT International Association.